The embedded model defines and solves the fluid flow equations and the equations for transport and reaction of biomolecules, including the kinetics for the surface reactions. The animation below shows the time-dependent concentration field of the measured biomolecules as a 3D surface where the height and color of the surface indicates concentration , after injection of the analyte. Animation showing the concentration field of a biomolecule in the analyte sweeping over the pillars like a wave.
The sweeping wave of biomolecules caused by the injection of analyte is also seen on the concentration at the surface of the pillars, as you can see in the app screenshot below. The blue solid line shows the concentration in the first row of pillars and in the middle of the channel.
The blue dash-dotted line shows the detected concentration at the surface of the pillars in the back row in the middle of the channel. The red solid curve represents the concentration of the biomolecule at the surface of the pillars positioned in the first row close to the wall of the cell. The red dash-dotted line shows the concentration measured by the pillars in the back row but close to the wall of the cell.
The pillars close to the walls and at the back of the cell both contribute to a broadening of the signal from the biosensor. In this case, it may be a good idea to decrease the number of pillars at the cost of a weaker but more well-defined signal.
Concentration of the measured biomolecule at the surface of the enzyme-coated pillars at different positions in the cell. The app demonstrated here is one example of countless possible biosensor design configurations.
This specific configuration may not be optimal for your purposes, but the app can be broadly used by you to build similar apps with clear and simple interfaces that inspire users to simulate and improve the design of biosensors. This consent may be withdrawn. Sir, in this design, only the upper adsorptive layer is simulated which is used for detection. But, if we want to design the whole biosensor like magnetic biosensors, in that case, will it be possible to couple this model as with magnetostatics to reflect the changes after detection?
You can fix this by pressing 'F12' on your keyboard, Selecting 'Document Mode' and choosing 'standards' or the latest version listed if standards is not an option. Log Out Log In Contact. May 12, From Descriptive to Hypothesis-Driven Research Theory and simulations, assisted by clever experimental techniques, have allowed for an increased detailed mechanistic understanding of biological systems, at the molecular level.
Enzymes as Detectors The figure below shows one possible arrangement of detector micropillars in a biosensor subjected to an analyte flow from left to right. Simulation of Injection and Detection of Biomolecules The animation below shows the time-dependent concentration field of the measured biomolecules as a 3D surface where the height and color of the surface indicates concentration , after injection of the analyte.
Get New Posts by Email. Leave a Comment. Suggested Posts. This demo app features a flow cell with active surfaces. The app allows the user to change design parameters of the sensor such as pillar diameter, grid spacing, and inlet velocity, and see how it affects the detection results. This application example illustrates applications of this type that would nominally be built using the following products:. Furthermore, this example may also be defined and modeled using components from the following product combinations:.
Particular functionality may be common to several products. To determine the right combination of products for your modeling needs, review the Specification Chart and make use of a free evaluation license. You can fix this by pressing 'F12' on your keyboard, Selecting 'Document Mode' and choosing 'standards' or the latest version listed if standards is not an option.
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